ea0049gp105 | Diabetes therapy & complications 2 | ECE2017
Bielohuby Maximilian
, Prakash Surya
, Brunner Bodo
, Pfenninger Anja
, Werner Ulrich
, Turpin-Nolan Sarah
, Bruning Jens
, Tennagels Norbert
Excess consumption of saturated fatty acids may lead to an increased production of ceramides that contribute to development of insulin resistance and type 2 diabetes. Substantial research demonstrated that inhibition of ceramide biosynthesis ameliorates atherosclerosis, hepatic steatosis, insulin resistance and obesity. However, as ceramides and their sphingolipid products are involved in multiple fundamental cellular processes, concerns exist about possible risks or adverse e...